Biography
Professor Yongguang Yang has been engaged in immunology (mainly transplantation and tumor immunity) research for more than 20 years. He is in the leading position in the field of establishing and applying humanized mouse models of immune system. His team has acquired a series of original achievements in the research field of transplantation immunity, stem cell immunity, tumor immunity and immunotherapy including the first evidence that hematopoietic chimeras can induce pre-existing and newly a1,3Gal antibodies to produce B lymphocyte immune tolerance; the first international theory that CD47 participates in transplantation immune rejection and immune tolerance; the main mechanism that macrophage immune tolerance and CD47 incompatibility were to trigger rejection of xenotransplantated macrophages. He constructed the humanized mice models with human immune system by the transplantation of the human thymus/hematopoietic stem cells, which were internationally recognized and widely used. And on the above basis, many new humanized mice models of diseases were established.