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  • Introduction 

    Translational immunology is a concept coming from translational medicine, the essence of which is to deeply investigate the role of immune system in controlling or facilitating the progress of immune relevant diseases, and develop novel immunological intervention strategies to treat the diseases. Specific areas that our research mainly focus on: Developing effective strategies for inducing allo- and xeno-transplant tolerance; Investigating mechanisms of xenograft rejection by innate immune responses; Generating “humanized” pig organs for safe and effective xenotransplantation; Uncovering mechanisms of tumor-induced immunosuppression; Developing tumor microenvironment-targeted cancer immunotherapy; Establishing humanized mouse (e.g., PDX) models for preclinical cancer immunotherapy; Developing humanized autoimmune disease animal models for investigating immunopathogenesis and testing therapeutic interventions of human autoimmune disease; Structural and molecular mechanism of target epigenetic proteins in immunobiology and immunological-relevant diseases; Study of the role of chromatin modifications and molecular interactions in epigenetic control of gene expression; Structural mechanism-guided rational design and development of novel small molecule compounds targeting epigenetic proteins in gene expression.

    Research Interest

    Developing effective strategies for inducing allo- and xeno-transplant tolerance; Investigating mechanisms of xenograft rejection by innate immune responses; Generating “humanized” pig organs for safe and effective xenotransplantation; Uncovering mechanisms of tumor-induced immunosuppression; Developing tumor microenvironment-targeted cancer immunotherapy; Establishing humanized mouse (e.g., PDX) models for preclinical cancer immunotherapy; Developing humanized autoimmune disease animal models for investigating immunopathogenesis and testing therapeutic interventions of human autoimmune disease; Structural and molecular mechanism of target epigenetic proteins in immunobiology and immunological-relevant diseases; Study of the role of chromatin modifications and molecular interactions in epigenetic control of gene expression; Structural mechanism-guided rational design and development of novel small molecule compounds targeting epigenetic proteins in gene expression.