Room-temperature superconductivity has been a long-held dream of condensed matter physics for over a century. Here, we predict a class of thermodynamically stable clathrate hydrides consisting of two previously unreported H₂₄ and H₃₀ cages at megabar pressures. Among these hydrides, LaSc₂H₂₄ is estimated to exhibit superconductivity with Tc up to 316 K at 167 GPa even when considering the effects of anharmonicity. Such “hot” superconductivity above room temperature is attributed to an unusually large hydrogen-derived density of states at the Fermi level arising from the unusual combination of H₃₀ and H₂₄ cages of this structure. Further exploration of the La–Sc–H ternary system is expected to facilitate the creation of other high-temperature superconductors.